Hoʻolauna piha
ʻO 3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) he lāʻau lapaʻau koʻikoʻi koʻikoʻi i hoʻohana nui ʻia i ka hoʻohuihui lāʻau lāʻau ikaika (API). He hana koʻikoʻi kēia ether heterocyclic ʻeono ma ke ʻano he mea pale no nā hui hydroxyl ma o ka hoʻokumu ʻana i nā eter tetrahydropyranyl (THP). ʻO kona hiki ke uhi i nā hana waiʻona ma lalo o nā kūlana acidic haʻahaʻa a hoʻihoʻi hou iā lākou ma lalo o ka wai aqueous he mea nui ia i ka synthesis lāʻau multistep.
Hana ʻia ma o ka hydrogenation o dihydropyran a i ʻole biomass -furfural i loaʻa, ua hoʻohālikelike ʻo DHP me nā loina kemika ʻōmaʻomaʻo. ʻO kāna hana ʻelua ma ke ʻano he mea hoʻomalu a me ka reactive intermediate ua hoʻopaʻa i kona waiwai i ka hana ʻana i nā corticosteroids, macrolide antibiotics, a me HIV protease inhibitors, ma waena o nā API -kiʻekiʻe.
Nā kikoʻī huahana
| Inoa Huahana | 3,4-Dihydro-2H-pyran |
| CAS NO. | 110-87-2 |
| Nā huaʻōlelo like | DHP |
| ʻAno Molekala | C5H8O |
| HS Code | 2932999099 |
| ʻO ke kumu hoʻohālike |  |
Hōʻike
|
Nā mea |
Kūlana |
|
Ka nana aku |
ʻO ka wai ʻākala kala ʻole |
|
Maʻemaʻe (%) |
ʻOi aku a i ʻole like me 98.5 |
|
Mākū (%) |
He emi a like paha me 0.25 |
|
THP(%) |
1.3 ka nui |
| Māmā (g/cm³) | 0.922 |
Hoʻohana a me ka hana kumu i loko o ka lāʻau lapaʻau Synthesis
- Palekana Hydroxyl i ka Hoʻomohala API:
Hoʻohana ʻia ʻo DHP no ka pale ʻana i nā pūʻulu waiʻona i nā mea waena lāʻau e like me nā eter THP. Paʻa kēia mau pūʻulu ma lalo o nā kūlana kumu a me ka nucleophilic a hiki ke wehe maʻemaʻe me ka hoʻohana ʻana i nā waikawa dilute.
- ʻO ka hui ʻana o nā ʻano he nui:
Hoʻomaʻamaʻa i nā ala synthesis kahi i loaʻa i ka waiʻona -mea waena e pono e hana hou me ka ʻole o nā ʻaoʻao.
- ʻO nā noi nui i ka hoʻohui ʻana i ka lāʻau lapaʻau:
Erythromycin (macrolide antibiotic):Hoʻohana ʻia ka DHP no ka pale hydroxyl koho i ka wā o ka hoʻokumu ʻana i ke apo.
ʻO nā corticosteroids:Mālama i nā pūʻulu hydroxyl i ka wā o ka hoʻonohonoho hou ʻana o ke apo paʻakikī a me nā pae oxidation.
ʻO ka HIV Protease Inhibitors:I nā lāʻau peptidomimetic, kōkua ka DHP i ka hoʻopaʻa ʻana i nā kaulahao ʻaoʻao i ka wā condensation a me ka cyclization.
- Kūwaena Kemika Green:
Hiki ke loa'a mai ka furfural-he biomass-kemika-ho'onoho i ka DHP ma ke 'ano he kikowaena pa'a no ka ho'ohana lā'au.
Kapa Hana Hana
-Paʻa Paʻa Paʻa Palekana
Manaʻo ʻia nā huahana huahana
Synthesis o nā macrolides a me nā aminoglycosides
ʻO ka hoʻopili ʻana i ka lāʻau steroidal (e laʻa, hydrocortisone, dexamethasone)
ʻO ka hoʻomohala ʻana i ka lāʻau peptide a me ka peptidomimetic
Palena hydroxyl koho i loko o nā ʻōpala lāʻau ma muli o ka carbohydrate-.
Kaʻina hana kemika no ka hoʻonui-o nā moho lāʻau lapaʻau
Hoʻopili
Hoʻopaʻa ʻia i loko: 180 kg pahu (nui), 1L/5L ʻōmole (laboratory or pilot scale)
FAQ
Nīnau: No ke aha he mea nui ka DHP i ka synthesis lāʻau?
A: Hāʻawi ia i ka pale koho o nā pūʻulu hydroxyl, e ʻae ana i ka synthesis lāʻau multistep e holo pono me ka ʻole o nā ʻaoʻao.
Nīnau: Hiki ke hoʻohana ʻia ka DHP i nā kaʻina GMP?
A: ʻAe. He kūpono ka DHP -ma'ema'e ki'eki'e no nā kaiapuni i ho'oponopono 'ia ke kāko'o 'ia e nā kiko'ī a me nā COA.
Nīnau: Pehea ka hoʻohuli ʻana o ka pale THP i ka hoʻohui lāʻau?
A: Wehe ʻia nā pūʻulu THP me ka hoʻohana ʻana i ka ʻakika liʻiliʻi (e laʻa, aqueous acetic acid), e hoʻihoʻi i ka waiʻona manuahi no nā hana aʻe.
Hōʻike
|
Nā mea |
Kūlana |
|
Ka nana aku |
ʻO ka wai ʻākala kala ʻole |
|
Maʻemaʻe (%) |
ʻOi aku a i ʻole like me 98.5 |
|
Mākū (%) |
He emi a like paha me 0.25 |
|
THP(%) |
1.3 ka nui |
| Māmā (g/cm³) | 0.922 |
Nā huahana pale: pharmaceutical intermediate 3,4-dihydro-2h-pyran, Kina pharmaceutical intermediate 3,4-dihydro-2h-pyran mea hana, mea hoʻolako, hale hana
